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H 1 How to make good resolutions

Auteurs : Véber, Amandine (Auteur de la Conférence)
CIRM (Editeur )

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    Résumé : In this presentation, we shall discuss the reconstruction of demographic parameters based on the genetic variability observed within a sample of individual DNA. In the family of models that we consider, the statistics describing this genetic diversity (number of mutations, distribution of the mutations amongst individuals in the sample) depend on a more or less coarse ‘resolution of (i.e., level of information on) the hidden genealogical tree that relates the sampled individuals. Considering the optimal resolution thus allows to greatly improve the exploration of the space of possible genealogies when computing the likelihood of demographic parameters, compared to classical methods based on full labelled trees such as Kingmans coalescent. We shall focus on two examples, based on works with Raazesh Sainudiin (Uppsala Univ.) and with Julia Palacios (Stanford Univ.), Sohini Ramachandran (Brown Univ.) and John Wakeley (Harvard Univ.).

    Codes MSC :
    60J10 - Markov chains (discrete-time Markov processes on discrete state spaces)
    60J27 - Continuous-time Markov processes on discrete state spaces
    92D15 - Problems related to evolution
    92D20 - Protein sequences, DNA sequences

      Informations sur la Vidéo

      Réalisateur : Hennenfent, Guillaume
      Langue : Anglais
      Date de publication : 28/06/2018
      Date de captation : 28/06/2018
      Collection : Research talks ; Mathematics in Science and Technology ; Probability and Statistics
      Format : MP4
      Durée : 00:52:26
      Domaine : Mathematics in Science & Technology ; Probability & Statistics
      Audience : Chercheurs ; Doctorants , Post - Doctorants
      Download : https://videos.cirm-math.fr/2018-06-28_Veber.mp4

    Informations sur la rencontre

    Nom de la rencontre : Probability and biological evolution / Probabilités et évolution biologique
    Organisateurs de la rencontre : Pardoux, Etienne ; Wakolbinger, Anton
    Dates : 25/06/2018 - 29/06/2018
    Année de la rencontre : 2018
    URL Congrès : https://conferences.cirm-math.fr/1774.html

    Citation Data

    DOI : 10.24350/CIRM.V.19418703
    Cite this video as: Véber, Amandine (2018). How to make good resolutions. CIRM. Audiovisual resource. doi:10.24350/CIRM.V.19418703
    URI : http://dx.doi.org/10.24350/CIRM.V.19418703


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