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H 1 Mathematical models and their applications in hypertension and autism

Auteurs : Layton, Anita T. (Auteur de la Conférence)
CIRM (Editeur )

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    Résumé : Computational modeling can be used to reveal insights into the mechanisms and potential side effects of a new drug. Here we will focus on two major diseases: diabetes, which affects 1 in 10 people in North America, and hypertension, which affects 1 in 3 adults. For diabetes, we are interested in a class of relatively novel drug treatment, the SGLT2 inhibitors (sodium-glucose co-transporter 2 inhibitors). E.g., Dapagliflozin, Canagliflozin, and Empagliflozin. We conduct simulations to better understand any side effect these drugs may have on our kidneys (which are the targets of SGLT2 inhibitors). Interestingly, these drugs may have both positive and negative side effects. For hypertension, we want to better understand the sex differences in the efficacy of some of the drug treatments. Women generally respond better to ARBs (angiotensin receptor blockers) than ACE inhibitors (angiontensin converting enzyme inhibitors), whereas the opposite is true for men. We have developed the first sex-specific computational model of blood pressure regulation, and applied that model to assess whether the ”one-size-fits-all” approach to blood pressure control is appropriate with regards to sex.

    Keywords : renal physiology; multiscale modeling; network analysis

    Codes MSC :
    92C20 - Neural biology
    92C40 - Biochemistry, molecular biology
    92C42 - Systems biology, networks

      Informations sur la Vidéo

      Réalisateur : Hennenfent, Guillaume
      Langue : Anglais
      Date de publication : 17/03/2020
      Date de captation : 27/02/2020
      Collection : Research talks ; Dynamical Systems and Ordinary Differential Equations ; Partial Differential Equations
      Format : MP4
      Durée : 00:52:29
      Domaine : PDE ; Dynamical Systems & ODE
      Audience : Chercheurs ; Doctorants , Post - Doctorants
      Download : https://videos.cirm-math.fr/2020-02-27_Layton.mp4

    Informations sur la rencontre

    Nom de la rencontre : Thematic Month Week 4: Mathematics of Complex Systems in Biology and Medicine / Mois thématique Semaine 4 : Mathématiques des systèmes complexes en biologie et en médecine
    Organisateurs de la rencontre : Cristofol, Michel ; Freyermuth, Jean-Marc ; Gomez, Christophe ; Hubert, Florence ; Ryan, Shawn ; Tournus, Magali
    Dates : 24/02/2020 - 28/02/2020
    Année de la rencontre : 2020
    URL Congrès : https://conferences.cirm-math.fr/2304.html

    Citation Data

    DOI : 10.24350/CIRM.V.19617103
    Cite this video as: Layton, Anita T. (2020). Mathematical models and their applications in hypertension and autism. CIRM. Audiovisual resource. doi:10.24350/CIRM.V.19617103
    URI : http://dx.doi.org/10.24350/CIRM.V.19617103


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