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H 1 Mathematical modelling and investigation of macrophages heterogeneity and their impact on the evolution of the cancer

Auteurs : Eftimie, Raluca (Auteur de la Conférence)
CIRM (Editeur )

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    Résumé : Macrophages are a type of immune cells that can be present in high numbers in some solid tumours. The heterogeneity of macrophage populations (with the anti-tumour M1 cells and thepro-tumour M2 cells being the two extreme phenotypes) has led to difficulties in understanding the innate immune responses to tumours. Here we introduce a class of mathematical models for the interactions between a population of tumour-associated macrophages (structured by their phenotype) and a population of cancer cells (that could be structured by their mutation status). We then use this class of models to confirm that the M1 cells kill tumours, while the M2 cells can lead to tumour growth. In addition, we show that macrophages with mixed phenotypes can contribute to either tumour growth or tumour decay. We also show that tumour dormancy is associated not only with an increased heterogeneity of cancer population, but also with an increased heterogeneity of macrophage population.

    Keywords : ODE; structured-population model; cancer; macrophage

    Codes MSC :
    35L60 - Nonlinear first-order hyperbolic equations
    92C15 - Developmental biology, pattern formation
    92C42 - Systems biology, networks

    Ressources complémentaires :

      Informations sur la Vidéo

      Réalisateur : Hennenfent, Guillaume
      Langue : Anglais
      Date de publication : 17/03/2020
      Date de captation : 27/02/2020
      Collection : Research talks ; Dynamical Systems and Ordinary Differential Equations ; Partial Differential Equations
      Format : MP4
      Durée : 00:45:37
      Domaine : PDE ; Dynamical Systems & ODE
      Audience : Chercheurs ; Doctorants , Post - Doctorants
      Download : https://videos.cirm-math.fr/2020-02-27_Eftimie.mp4

    Informations sur la rencontre

    Nom de la rencontre : Thematic Month Week 4: Mathematics of Complex Systems in Biology and Medicine / Mois thématique Semaine 4 : Mathématiques des systèmes complexes en biologie et en médecine
    Organisateurs de la rencontre : Cristofol, Michel ; Freyermuth, Jean-Marc ; Gomez, Christophe ; Hubert, Florence ; Ryan, Shawn ; Tournus, Magali
    Dates : 24/02/2020 - 28/02/2020
    Année de la rencontre : 2020
    URL Congrès : https://conferences.cirm-math.fr/2304.html

    Citation Data

    DOI : 10.24350/CIRM.V.19617203
    Cite this video as: Eftimie, Raluca (2020). Mathematical modelling and investigation of macrophages heterogeneity and their impact on the evolution of the cancer. CIRM. Audiovisual resource. doi:10.24350/CIRM.V.19617203
    URI : http://dx.doi.org/10.24350/CIRM.V.19617203

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