We will present in this talk a mathematical model for a mixture composed by solid particles immersed in a viscous liquid. In a dense regime (high concentration of solid particles), the lubrication effects are predominant in the dynamics. Our goal is to study mathematically a minimal effective model, based on compressible Navier-Stokes equations, which take into account lubrication effects via a singular dissipation term. We will also consider the regime where the viscosity of the interstitial fluid tends to 0.[-]

At the individual scale, bacteria as E. coli move by performing so-called run-and-tumble movements. This means that they alternate a jump (run phase) followed by fast re-organization phase (tumble) in which they decide of a new direction for run. For this reason, the population is described by a kinetic-Botlzmann equation of scattering type. Nonlinearity occurs when one takes into account chemotaxis, the release by the individual cells of a chemical in the environment and response by the population.

These models can explain experimental observations, fit precise measurements and sustain various scales. They also allow to derive, in the diffusion limit, macroscopic models (at the population scale), as the Flux-Limited Keller-Segel system, in opposition to the traditional Keller-Segel system, this model can sustain robust traveling bands as observed in Adler's famous experiment.

Furthermore, the modulation of the tumbles, can be understood using intracellular molecular pathways. Then, the kinetic-Boltzmann equation can be derived with a fast reaction scale. Long runs at the individual scale and abnormal diffusion at the population scale, can also be derived mathematically.[-]